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ini in Windows located in the directory specified by the SYBASE environment variable; for example, ini directory in Windows. Specifies a Sybase IQ login name. If you do not specify -P passwordiq_bcp prompts for a password. Specifies a Sybase IQ password. You can omit the -P flag if the password is NULL. Use this cross-platform file format if you are sharing data between platforms. Specifies the Sybase IQ server name to which iq_bcp connects. Specifies the name and location of the interface file to search when connecting to Sybase IQ.

Performs the copy operation. Open-client based utility that copies a database table to or from an operating system file in a user-specified format. This parameter does not prompt for each field; it uses CHAR as the default storage type of all columns in the data file, no prefixes, t tab as the default field terminator, and n new line as the default row terminator. The iq_bcp utility supports multi-byte character data.

When inserting or extracting data, the -J flag converts data from server character set to client character set. Specifies the client character set. Omitting -J sets the client charset to that platform†s default, potentially causing incorrect data conversion because the default charset might not be what the client is using. Displays the version number and copyright message of iq_bcp and returns to the operating system.

Specifies the default field terminator. For more information on character sets, see Chapter 11, “International Languages and Character Sets” in the Sybase IQ System Administration Guide. Specifies the default row terminator. When specifying terminators from the command line with the -t or -r parameter, you must escape characters that have special significance to the UNIX operating system or the command prompt shell for Windows.

This is not necessary when iq_bcp prompts you interactive mode. Results are unpredictable and data may become corrupted. В Do not use -t or -r parameters with iq_bcp in native format. Specifies the network packet size to use for this iq_bcp session. The following example sets the packet size to 4096 bytes. packet_size must be between the values of the default network packet size and maximum network packet size configuration variables, and it must be a multiple of 512.

Use network packet sizes larger than the default to improve the performance of large bulk-copy operations. iq_bcp filters out unsupported options by BCP and supports additional options listed in Table 3-1. For all unsupported options, iq_bcp displays a message. You can view this information by issuing the following command without parameters. iq_bcp offers two modes, iq_bcp in and iq_bcp out. When executing a bulk copy in or out option, iq_bcp offers two formats for saving or reading the file native and cross-platform.

Sybase IQ supports cross-platform file format only. Native file format is not supported by Sybase IQ in any bulk copy operation. Data to be inserted into Sybase IQ tables via iq_bcp must be imported in cross-platform file format using the -c option. The following tables illustrate the supported ASE data types for the iq_bcp in operation. IQ data types. Unsigned Big Int. ASE data types. The support for character data types is limited to input values of size less than 32KB.

For binary data type support to work, a database option, ASE_Binary_Displaymust be set to OFF in IQ server. The default value of this option is ON. See “ASE_BINARY_DISPLAY option,” “Database Options,” in the Sybase IQ Reference Manual. For BINARY data type, support is limited to column size of less than 256 bytes. The ASE data type BIT is supported by the corresponding Sybase IQ data type BIT.

For VARBINARY and LONG BINARY data types, support is limited to column size of less than 32KB. Either place a backslash in front of the special character or enclose it in quotes. All supported data types listed in Table 3-2 through Table 3-5 are supported for conversion to any Sybase IQ data type, as long as the value can be implicitly converted. Table 7-8 in Chapter 7, “Moving Data In and Out of Databases” of the Sybase IQ System Administration Guide describes the supported implicit data conversions used by Sybase IQ during an INSERT operation.

Sybase IQ supports additional data types, which are not directly compatible with any ASE data type. Table 3-6, illustrates all the Sybase IQ data types along with its equivalent data types in ASE, BCP and ASA. Table 3-6 does not list aliases or domains defined in Sybase IQ. Numeric data types. Unsigned Tiny Int. Signed Small Int. Character data types. Bit data types. Bit allowing null. Binary data types. Date data types.

The only non-ASE data type supported for the iq_bcp in and iq_bcp out operation is nullable BIT data type. Data to be extracted from Sybase IQ tables, including data from ASE and ASA tables meant for import back in Sybase IQ tables, must be exported in cross-platform file format using the iq option fibonacci option. The precision specifies the maximum number of decimal digits that can be stored in the column.

It includes all digits, both to the right and left of the decimal point. You can specify precisions ranging from 1 digit to 38 digits or use the default precision of 18 digits. If any character column value in the input contains a space or spaces alone, a zero-length string is inserted in the table†s corresponding column. If a table contains a decimal column, iq_bcp out is supported on that table only if the precision of the decimal column is less than or equal to 38 digits.

Non-default values for server options, except TEXTSIZE, do not take effect for the iq_bcp client. Table 7-8 in Chapter 7, “Moving Data In and Out of Databases” of the Sybase IQ System Administration Guide. Chapter 4, “SQL Data Types” in the Sybase IQ Reference Manual. Burnham 105648-01 IQ Option Card IQ Control System Outdoor Air Temperature Reset Includes Sensor and Sensor Lead for Iq option fibonacci Series 3 ESC MPO-IQ Series Boilers 102723-01.

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Northwestern University scientists sprint to develop new kind of rapid coronavirus test Trump announces 60-day pause on green cards to limit competition for US jobs amid coronavirus but will allow temporary workers. The Senate just approved 310 billion more for PPP loans. These Chicago businesses are waiting for their turn at the funds. 2 trillion federal coronavirus relief package have been left in financial limbo, growing increasingly frustrated as they wait for Congress to allocate more money.

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Matt Molenkamp, 24, had been looking for work for a year before Earth Paint came into his life. Federal lawmakers reached a tentative agreement for an additional 310 billion in funding for the paycheck program, part of a 484 billion coronavirus relief bill passed Tuesday by the Senate, but there are signs even that sum may not be enough. Having a disability and getting employed can be hard, said the Wood Dale resident, who has cerebral palsy.

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FDA Drug Safety Communication FDA warns about serious heart problems with high doses of the antidiarrheal medicine loperamide Imodiumincluding from abuse and misuse. 06-07-2016 The U. Food and Drug Administration FDA is warning that taking higher than recommended doses of the common over-the-counter OTC and prescription diarrhea medicine loperamide Imodiumincluding through abuse or misuse of the product, can cause serious heart problems that can lead to death.

The risk of these serious heart problems, including abnormal heart rhythms, may also be increased when high doses of loperamide are taken with several kinds of medicines that interact with loperamide see Examples of Drugs that Can Potentially Interact with Loperamide. The majority of reported serious heart problems occurred in individuals who were intentionally misusing and abusing high doses of loperamide in attempts to self-treat opioid withdrawal symptoms or to achieve a feeling of euphoria.

We continue to evaluate this safety issue and will determine if additional FDA actions are needed. Health care professionals should be aware that use of higher than recommended doses of loperamide can result in serious cardiac adverse events. Consider loperamide as a possible cause of unexplained cardiac events including QT interval prolongation, Torsades de Pointes or other ventricular arrhythmias, syncope, and cardiac arrest. In cases of abuse, individuals often use other drugs together with loperamide in attempts to increase its absorption and penetration across the blood-brain barrier, inhibit loperamide metabolism, and enhance its euphoric effects.

If loperamide toxicity is suspected, promptly discontinue the drug and start necessary therapy. If loperamide ingestion is suspected, measure blood levels, which may require specific testing. For some cases of Torsades de Pointes in which drug treatment is ineffective, electrical pacing or cardioversion may be required. Advise patients taking loperamide to follow the dosing recommendations on the label because taking higher than recommended doses, either intentionally or unintentionally, may lead to abnormal heart rhythms and serious cardiac events leading to death.

Refer patients with opioid use disorders for treatment see Additional Information for Health Care Professionals. Also advise patients that drug interactions with commonly used medicines also increase the risk of serious cardiac adverse events. Do not use more than the dose prescribed or listed on the label, as doing so can cause severe heart rhythm problems or death.

If your diarrhea lasts more than 2 days, stop taking loperamide and contact your health care professional. Patients and consumers should only take loperamide in the dose directed by their health care professionals or according to the OTC Drug Facts label. Seek medical attention immediately by calling 911 if you or someone taking loperamide experiences any of the following.

Fainting Rapid heartbeat or irregular heart rhythm Unresponsiveness, meaning that you can t wake the person up or the person doesn t answer or react normally. Loperamide is approved to help control symptoms of diarrhea, including Travelers Diarrhea. Always tell your health care professionals about all the medicines you are taking, including OTC medicines see Examples of Drugs that Can Potentially Interact with Loperamide.

Ask a pharmacist or your health care professional if you are not sure how much loperamide to take, how often to take it, or whether a medicine you are taking may interact with loperamide. The maximum approved daily dose for adults is 8 mg per day for OTC use and 16 mg per day for prescription use. It is sold under the OTC brand name Imodium A-D, as store brands, and as generics.

In the 39 years from when loperamide was first approved in 1976 through 2015, FDA received reports of 48 cases of serious heart problems associated with use of loperamide. This number includes only reports submitted to FDA, so there are likely additional cases about which we are unaware. Thirty-one of these cases resulted in hospitalizations, and 10 patients died.

In other cases, patients were taking the recommended dose of loperamide, but they were also taking interacting medicines, causing an increase in loperamide levels. Additional cases of serious heart problems associated with the use of loperamide were reported in the medical literature. More than half of the 48 cases were reported after 2010. The serious heart problems occurred mostly in patients who were taking doses that were much higher than recommended. 1-9 Cases reported to FDA and in the medical literature indicate that individuals are taking significantly high doses of loperamide in situations of both misuse and abuse, often attempting to achieve euphoria or self-treat opioid withdrawal.

They are also combining loperamide with interacting drugs in attempts to increase these effects. We urge patients, consumers, and health care professionals to report side effects involving loperamide or other medicines to the FDA MedWatch program, using the information in the Contact FDA box at the bottom of the page. Examples of Drugs that Can Potentially Interact with Loperamide. This is not a complete list, and the extent of the effects of each drug are unknown.

If you are not sure if a medicine you are taking interacts with loperamide, ask a pharmacist or your health care professional. Generic Name Examples of Brand Name s cimetidine Tagamet HB clarithromycin Biaxin, Prevpac erythromycin E.Ery-Tab, Eryc, Eryped, PCE gemfibrozil Lopid itraconazole Onmel,Sporanox ketoconazole Available by generic only quinidine Nuedexta quinine Qualaquin ranitidine Zantac ritonavir Kaletra, Norvir, Technivie, Viekira Pak. Quinine and its isomer quinidine are also present in Tonic Water.

Facts about loperamide. It is sold over-the-counter OTC under the brand name Imodium A-D, as store brands, and as generics. The majority of single-ingredient loperamide sold in the U. It is also available by prescription. Loperamide is approved for use in single doses of 4 mg for the first dose followed by 2 mg after each loose stool for adults. Loperamide acts on opioid receptors in the gut to slow down the movement of the intestines.

The maximum approved total daily dose is 8 mg per day for OTC use and 16 mg per day for prescription use. Loperamide is not recommended for use in children younger than 2 years. Dosing for children depends on the age of the child. Loperamide is available as a tablet, capsule, or liquid to take by mouth. Although it is usually taken after each loose stool, it is important not to exceed the total daily dose that is recommended on the drug label or prescribed by your health care professional.

Common side effects include dry mouth, dizziness, drowsiness, stomach discomfort, nausea or vomiting, and constipation. Loperamide can interact with antifungal drugs such as itraconazole and ketoconazole; the cholesterol drug gemfibrozil; the heart drug quinidine; the antimalarial drug quinine; the HIV drug ritonavir; drugs to treat acid reflux including histamine type 2 receptor antagonists H2RAs ; and the antibiotics erythromycin and clarithromycin see Examples of Drugs that Can Potentially Interact with Loperamide.

Additional Information for Patients and Consumers. Any of these drugs when taken with loperamide can increase loperamide blood levels. Taking higher than the recommended dose of the antidiarrheal medicine loperamide can lead to serious heart problems, including abnormal heart rhythms and death. Use no more than the dose of loperamide listed on the label or prescribed by your health care professional. This decreases the number of bowel movements and makes stools less watery.

Taking loperamide with several kinds of commonly used medicines can increase the level of loperamide in the body and can raise the risk of these serious heart problems and death, especially if you take more than the recommended dose of loperamide. Always tell your health care professionals about all the medicines you are taking, including over-the-counter OTC medicines, vitamins, and other supplements. See Examples of Drugs that Can Potentially Interact with Loperamide.

Seek medical attention immediately if you or someone taking loperamide experiences any of the following fainting; rapid heartbeat or irregular heart rhythm; or unresponsiveness, meaning that you can t wake the person up or the person doesn t answer or react normally. If you are not sure how much loperamide to take, how often to take it, or whether a medicine you are taking interacts with loperamide, ask a pharmacist or your health care professional.

Always read the Drug Facts labels included on all OTC medicines to find out how much and how often you should take them and if the medicines contain loperamide. Stop taking loperamide and contact your health care professional if your diarrhea lasts more than 2 days, your symptoms get worse, or you get abdominal swelling or bulging. Do not give loperamide to a child younger than 2 years unless directed by a health care professional. Report side effects from loperamide or other medicines to the FDA MedWatch program, using the information in the Contact FDA box at the bottom of this page.

Consider loperamide as a possible cause of these unexplained cardiac events. In some reported cases, these events were not attributed to loperamide, resulting in ineffective and or delayed treatment. If loperamide-induced cardiotoxicity is suspected, promptly discontinue loperamide and start therapy to manage and prevent cardiac arrhythmias and severe outcomes. Higher than recommended doses of loperamide can cause serious cardiac events, including QT interval prolongation, Torsades de Pointes, other ventricular arrhythmias, cardiac arrest, syncope, and death.

Measure blood levels of loperamide. Standard drug screens for opioids do not include an assay for loperamide; such testing for opioids will yield negative results even in the presence of loperamide. Consider electrical pacing or cardioversion for loperamide-associated Torsades de Pointes that persists despite pharmacotherapy. If you need to measure blood levels of loperamide, specifically request the test. In the majority of severe cases, individuals intentionally abused loperamide by taking massive doses to achieve a feeling of euphoria or prevent opioid withdrawal.

In many reported cases, antiarrhythmic medications were ineffective, and electrical pacing or cardioversion were required to control the arrhythmias. Some patients also misused loperamide by taking higher than recommended doses to treat diarrhea. In the most severe cases, individuals self-treated with doses ranging from 70 mg to 1600 mg daily, which is 4 to 100 times the recommended dose.

In several cases, individuals used concomitant drugs to increase gastrointestinal absorption, decrease loperamide metabolism, and increase blood brain barrier penetration.intraconazole, clarithromycinCYP2C8 inhibitors e. These drugs included CYP3A4 inhibitors e. With loperamide abuse, concomitant use of drugs that inhibit CYP3A4, CYP2C8, and or P-glycoprotein may increase the risk of serious cardiac events. Multiple drugs that act on different metabolic or transporter pathways may act synergistically to increase loperamide concentrations.

Loperamide is an opioid that has relatively low gastrointestinal absorption and poor blood-brain barrier penetration. At approved does, loperamide has a relatively long half-life of 9 to 13 hours.gemfibroziland P-glycoprotein inhibitors e. At doses of 16 mg and higher, the half-life has been found to be as high as 41 hours. Prescribe loperamide with caution in patients who are predisposed to QT interval prolongation, Torsades de Pointes, and other serious arrhythmias or who are on drugs that inhibit loperamide metabolism or transport i.

Counsel patients about the cardiac risks of loperamide and tell them not to use more than the recommended dose. Refer patients with opioid use disorders for treatment. There are FDA-approved drugs to reduce opioid withdrawal symptoms. Concomitant drugs may act synergistically to increase loperamide concentrations by blocking more than one pathway of loperamide elimination.CYP3A4, CYP2C8, or P-glycoprotein inhibitors.

Report adverse events involving loperamide or other drugs to the FDA MedWatch program, using the information in the Contact FDA box at the bottom of this page. Loperamide is not recommended for use in children under 2 years. A search of the FDA Adverse Event Reporting System FAERS database from December 28, 1976 initial FDA approvalthrough December 14, 2015, identified 48 cases of serious cardiac events with loperamide use.

The most frequently reported cardiac events were syncope n 24cardiac arrest n 13QT interval prolongation n 13ventricular tachycardia n 10and Torsades de Pointes n 7. Some cases reported more than one cardiac event. Ten cases resulted in death. Nine of the deaths were due to ingestion of large amounts of loperamide, and there was one sudden cardiac death after the patient ingested an unknown amount of loperamide.

In many cases, standard antiarrhythmic medications were ineffective and only electrical pacing resulted in control of the arrhythmias. Twenty-two of the 48 cases reported that the patients were abusing high doses of loperamide, and 17 cases reported that the patients were taking loperamide to treat diarrhea. Among the 17 patients who used loperamide for diarrhea, 11 reported taking therapeutic doses of loperamide, 5 reported using higher than recommended doses, and one did not report a loperamide dose.

Of the cases that reported a loperamide dose, the mean dose was 195 mg per day range 1 to 1600 mg per day. Of the cases that reported the duration of loperamide use, the duration ranged from less than 1 day to 18 months. Among the 11 cases that reported therapeutic doses, 2 were in children younger than 2 years, in whom loperamide use is not recommended. Several of the 48 cases indicated the patients were intentionally misusing concomitant drugs that are cytochrome P450 CYP3A4 or CYP2C8 or P-glycoprotein inhibitors, such as quinidine, which have the potential for drug-drug interactions with loperamide that can increase the blood levels and the effects of loperamide.

Seventeen of the 48 cases had a positive dechallenge following the discontinuation of loperamide, and 5 cases had a positive rechallenge with the reintroduction of loperamide. Of the five rechallenge cases, four were Torsades de Pointes and one was ventricular arrhythmia. One child experienced syncope and hypoventilation, and the other experienced ventricular tachycardia.

Four of these cases included patients taking recommended doses of loperamide. Twelve cases of Torsades de Pointes seven were reported as Torsades de Pointes and five were clinically consistent with it and 11 of the 13 cardiac arrest events including 8 cases resulting in deaths occurred with loperamide abuse or misuse.

In contrast, iq option fibonacci and ventricular tachycardia events occurred when patients took therapeutic doses of loperamide. We also searched the medical literature and identified additional cases of serious cardiac events with loperamide. 1-5 One case resulted in death, one was loperamide-induced Brugada syndrome, and three were Torsades de Pointes after ingesting large doses of loperamide.

In all three Torsades de Pointes cases, the patients self-treated their chronic diarrhea with massive doses of loperamide range 144-192 mg per day. Multiple advanced measures such as defibrillation and pacemaker insertion were needed. Since our review, four additional articles describing serious cardiac events with loperamide have been published, including two that resulted in death. Global Opportunities Option. The underlying managers strategies tend to have higher levels of risk and lower benchmark sensitivity than more traditional products.

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